StemRegenin 1

Product Description

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC₅₀ = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

Solubility

Preparing Stock Solutions for StemRegenin 1

The following data is based on the product molecular weight 429.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Koide Aryl hydrocarbon receptor antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4. Anticancer Res. 2016 PMID: 27354634
• Genovese Targeted genome editing in human repopulating haematopoietic stem cells. Nature 2014 PMID: 24870228
• Boitano Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010 PMID: 20688981
• Jackson Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 2017 PMID: 28445828