SNIPER(ER)-87
Tocris Bioscience, part of Bio-Techne | Catalog # 7120
Potent and selective ERα Degrader (SNIPER)
Key Product Details
Description
Potent and selective ERα Degrader (SNIPER)
Product Description
SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.Product Specifications
Molecular Weight
1044.32
Formula
C59H73N5O10S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
CAS Number
2222354-91-6
PubChem ID
155563319
InChI Key
ILLYWIKUEZHTSD-RJFLEHBVSA-N
SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(COCCOCCOCCOC3=CC(C(C4=CSC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=N4)=O)=CC=C3)=O)C)\C7=CC=C(C=C7)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 104.43 | 100 |
Preparing Stock Solutions
for SNIPER(ER)-87
The following data is based on the product molecular weight 1044.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.96 mL | 4.79 mL | 9.58 mL |
| 5 mM | 0.19 mL | 0.96 mL | 1.92 mL |
| 10 mM | 0.10 mL | 0.48 mL | 0.96 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ohoka In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 2017 PMID: 28154167
Product Specific Notices for SNIPER(ER)-87
For research use only
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