SM 102
Tocris Bioscience, part of Bio-Techne | Catalog # 8909
Cationic ionizable lipid
Product Description
SM 102 is an ionizable cationic lipid (pKa = 6.68) used in the formulation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. Administration of LNPs containing SM 102 induces hepatic luciferase expression in mice. SM 102 is commonly formulated with cholesterol (Cat. No. 7945), DSPC (Cat. No. 7943) , and DMG-PEG 2000 (Cat. No. 7944).This product is supplied pre-dissolved in anhydrous ethanol, 100mg/mL
For more information on LNPs and available components see our Lipid Nanoparticles page.
Product Specifications
Molecular Weight
710.17
Formula
C44H87NO5
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]octanoate
CAS Number
2089251-47-6
PubChem ID
126697616
InChI Key
BGNVBNJYBVCBJH-UHFFFAOYSA-N
SMILES
O=C(OCCCCCCCCCCC)CCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL) |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sabnis A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates. Mol.Ther. 2018 PMID: 29653760
- Hassett Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines. Mol Ther Nucleic Acids 2019 PMID: 30785039
Product Specific Notices for SM 102
For research use only
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