SJPYT 328 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8840
Potent and selective PXR1 agonist
Key Product Details
Description
Potent and selective PXR1 agonist
Product Description
SJPYT 328 is a potent and selective PXR1 agonist (IC50 = 7 nM). Displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 328 and SJPYT 310 (Cat. No. 8839) can be used as benchmark compounds for referencing "full agonist" and "full antagonist" when screening for new drugs in cellular models. SJPYT 328 shows no toxicity.Licensing Information
Sold under license from St. Jude Children's Research HospitalProduct Specifications
Molecular Weight
508.66
Formula
C29H40N4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(2,4-Dimethoxy-5-methylphenyl)-N-[5-(1,1-dimethylethyl)-2-[(1S)-1-ethylbutoxy]phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide
CAS Number
2998548-72-2
PubChem ID
169248098
InChI Key
VDHSAAKREKQAEL-NRFANRHFSA-N
SMILES
CC1=C(C(NC2=C(C=CC(C(C)(C)C)=C2)O[C@@H](CC)CCC)=O)N=NN1C3=C(C=C(OC)C(C)=C3)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.09 | 10 | |
| Ethanol | 5.09 | 10 |
Preparing Stock Solutions
for SJPYT 328
The following data is based on the product molecular weight 508.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.66 mL | 98.30 mL | 196.59 mL |
| 0.5 mM | 3.93 mL | 19.66 mL | 39.32 mL |
| 1 mM | 1.97 mL | 9.83 mL | 19.66 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Garcia-Maldonado Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat.Comms. 2024 PMID: 38744881
Product Specific Notices for SJPYT 328
For research use only
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