SJPYT 310

Name: SJPYT 310
Brand: Tocris Bioscience
SKU: 8839

Tocris Bioscience, part of Bio-Techne | Catalog # 8839

COA / SDS

Potent and selective PXR antagonist

Key Product Details

Description:	Potent and selective PXR antagonist
Chemical Name:	N-[5-(1,1-Dimethylethyl)-2-[(1S)-1-methylbutoxy]phenyl]-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	464.61

View Full Technical Details for SJPYT 310

Technical Data
Citations

Biological Activity for SJPYT 310

SJPYT 310 is a potent and selective PXR antagonist (IC₅₀ values are 4 and 9 nM for binding and cellular activity, respectively). SJPYT 310 displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 310 shows no toxicity.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Technical Data for SJPYT 310

M. Wt	464.61
Formula	C₂₇H₃₆N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2883814-84-2
PubChem ID	171352643
InChi Key	UOXKTTLWMUQDFC-SFHVURJKSA-N
Smiles	CC1=C(C(NC2=C(C=CC(C(C)(C)C)=C2)O[C@@H](C)CCC)=O)N=NN1C3=C(C=CC(C)=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJPYT 310

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.46	100
	ethanol	46.46	100

Preparing Stock Solutions for SJPYT 310

The following data is based on the product molecular weight 464.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.52 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SJPYT 310

References are publications that support the biological activity of the product.

Li Design and optimization of 1 H-1,2,3-Triazole-4-carboxamides as novel, potent, and selective inverse agonists and antagonists of PXR. J.Med.Chem. 2022 PMID: 36480704
Garcia-Maldonado Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat.Commun. 2024 PMID: 38744881