SCH 442416

Name: SCH 442416
Brand: Tocris Bioscience
SKU: 2463

Tocris Bioscience, part of Bio-Techne | Catalog # 2463

Citations (79)

COA / SDS

Very selective, high affinity A2A antagonist

Key Product Details

Description:	Very selective, high affinity A_2A antagonist
Chemical Name:	2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Purity:	≥98% (HPLC)
Molecular Weight:	389.42

View Full Technical Details for SCH 442416

Technical Data
Citations

Biological Activity for SCH 442416

SCH 442416 is a selective adenosine A_2A receptor antagonist; binds to human and rat A_2A receptors with high affinity (K_i values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA_2A over hA₁ in vitro with minimal affinity for hA_2B and hA₃ receptors (IC₅₀ > 10 μM). Blocks the cytoprotective effect of A_2A agonist CGS-21680 (Cat.No. 1063).

Compound Libraries for SCH 442416

SCH 442416 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 442416

M. Wt	389.42
Formula	C₂₀H₁₉N₇O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	316173-57-6
PubChem ID	10668061
InChi Key	AEULVFLPCJOBCE-UHFFFAOYSA-N
Smiles	COC1=CC=C(CCCN2N=CC3=C2N=C(N)N2N=C(N=C32)C2=CC=CO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 442416

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.94	100

Preparing Stock Solutions for SCH 442416

The following data is based on the product molecular weight 389.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for SCH 442416

References are publications that support the biological activity of the product.

Zheng Protective roles of adenosine A₁, A₂, and A₃ receptors in skeletal muscle ischemia and reperfusion injury. Am.J.Physiol.Heart Circ.Physiol.
Todde Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A_2A receptor system using positron emission tomography. J.Med.Chem. 2000 PMID: 11087559