CGS 21680 hydrochloride

Product Description

CGS 21680 hydrochloride is a potent A_2A adenosine receptor agonist (K_i = 27 nM, EC₅₀ = 1.48-180 nM). CGS 21680 reduces venous resistance, increases heart rate and cardiac output in vivo. In an animal model of Huntington's disease, CGS21680 slows motor deterioration, prevents reduction in brain weight and reduces the size of mutant huntingtin aggregates and intranuclear inclusions. CGS21680 increases proliferation of neural progenitor cells, promotes survival of motoneurons and activates TrkB receptors. Also has anti-inflammatory effects in animal models of lung injury and reduces neurotoxicity induced by Kainate (Cat. No. 7065).

Solubility

Preparing Stock Solutions for CGS 21680 hydrochloride

The following data is based on the product molecular weight 535.99

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.33 mL	18.66 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Komaki Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci.Lett. 2012 PMID: 22691937
• Rebola Different roles of adenosine A₁, A_2A and A₃ receptors in controlling kainate-induced toxicity in cortical cultured neurons. Neurochem.Int. 2005 PMID: 16011860
• Shryock A_2A-adenosine receptor reserve for coronary vasodilation. Circulation 1998 PMID: 9715864
• Wiese Adenosine receptor A_2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 17940030
• Chou CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. J.Neurochem. 2005 PMID: 15816854
• Phillis The selective adenosine A₂ receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res. 1990 PMID: 2322828
• Nekooeian and Tabrizchi Effects of CGS 21680, a selective A_2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat. Br.J.Pharmacol. 1998 PMID: 9605574
• Klot Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832