Rilpivirine
Tocris Bioscience, part of Bio-Techne | Catalog # 7684
Non-nucleoside reverse transcriptase inhibitor
Key Product Details
Description
Non-nucleoside reverse transcriptase inhibitor
Product Description
Rilpivirine is a potent diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It has high antiviral activity against wild-type HIV-1 and mutant viruses (EC50 values are 0.4 and 0.1-2.0 nM, respectively in a cell-based assay). This compound is orally bioavailable.Product Specifications
Molecular Weight
366.42
Formula
C22H18N6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
CAS Number
500287-72-9
PubChem ID
6451164
InChI Key
YIBOMRUWOWDFLG-ONEGZZNKSA-N
SMILES
N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.32 | 50 |
Preparing Stock Solutions
for Rilpivirine
The following data is based on the product molecular weight 366.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.46 mL | 27.29 mL | 54.58 mL |
| 2.5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Baert Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment. Eur.J.Pharm.Biopharm. 2009 PMID: 19328850
- Janssen In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) J.Med.Chem. 2005 PMID: 15771434
Product Specific Notices for Rilpivirine
For research use only
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