(R)-(-)-Phenylephrine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2838
α1 agonist
Product Description
(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.Scientific Data Images for (R)-(-)-Phenylephrine hydrochloride
Small molecules affect cardiomyocyte contraction rates.
The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cellsProduct Specifications
Molecular Weight
203.67
Formula
C9H13NO2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
CAS Number
61-76-7
PubChem ID
441279
InChI Key
OCYSGIYOVXAGKQ-FVGYRXGTSA-N
SMILES
OC1=CC=CC([C@@H](O)CNC)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.37 | 100 | |
| DMSO | 20.37 | 100 |
Preparing Stock Solutions
for (R)-(-)-Phenylephrine hydrochloride
The following data is based on the product molecular weight 203.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.91 mL | 24.55 mL | 49.10 mL |
| 5 mM | 0.98 mL | 4.91 mL | 9.82 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ford Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 1997 PMID: 9249248
- Morton α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 2007 PMID: 17115072
- Minneman Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 1994 PMID: 7969082
Product Specific Notices for (R)-(-)-Phenylephrine hydrochloride
For research use only
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