Pyrrolidinedithiocarbamate ammonium

Name: Pyrrolidinedithiocarbamate ammonium
Brand: Tocris Bioscience
SKU: 0727
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0727

(1)

Citations (2)

COA / SDS

Inhibits NF-κB, prevents increase in NOS mRNA

Discontinued Product

0727 has been discontinued. View all NFkB/IkB Inhibitors products.

Key Product Details

Description:	Inhibits NF-κB, prevents increase in NOS mRNA
Alternative Names:	PDTC
Molecular Weight:	164.28

View Full Technical Details for Pyrrolidinedithiocarbamate ammonium

Technical Data
Citations / Reviews (1)

Biological Activity for Pyrrolidinedithiocarbamate ammonium

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

Technical Data for Pyrrolidinedithiocarbamate ammonium

M. Wt	164.28
Formula	C₅H₁₂N₂S₂
Storage	Store at RT
CAS Number	5108-96-3
PubChem ID	73343
InChi Key	MDDIUTVUBYEEEM-UHFFFAOYSA-N
Smiles	[NH4+].[S-]C(N1CCCC1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Pyrrolidinedithiocarbamate ammonium

References are publications that support the biological activity of the product.

Eberhardt Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 1994 PMID: 7513157
Schini-Kerth Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 1994 PMID: 7533726
Bessho Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 1994 PMID: 7986199

Pyrrolidinedithiocarbamate ammonium

Tocris Bioscience, part of Bio-Techne | Catalog # 0727

Key Product Details

Biological Activity for Pyrrolidinedithiocarbamate ammonium

Technical Data for Pyrrolidinedithiocarbamate ammonium

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Pyrrolidinedithiocarbamate ammonium

Product Documents for Pyrrolidinedithiocarbamate ammonium

COA

Certificate of Analysis

SDS

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