PTC 209
Tocris Bioscience, part of Bio-Techne | Catalog # 5191
Bmi-1 inhibitor; antitumor
Discontinued Product
5191 has been discontinued.
View all Ubiquitin Ligase (E3) Inhibitors products.
Key Product Details
Description
Bmi-1 inhibitor; antitumor
Product Description
PTC 209 is a Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.Product Specifications
Molecular Weight
495.19
Formula
C17H13Br2N5OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
CAS Number
315704-66-6
PubChem ID
1117196
InChI Key
XVOOCQSWCCRVDY-UHFFFAOYSA-N
SMILES
CC3=C(N(C=CC=N4)C4=N3)C1=CSC(NC2=C(Br)C=C(OC)C=C2Br)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.52 | 100 | |
| Ethanol | 9.9 | 20 |
Preparing Stock Solutions
for PTC 209
The following data is based on the product molecular weight 495.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.10 mL | 20.19 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.04 mL |
| 10 mM | 0.20 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kreso Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med. 2014 PMID: 24292392
Product Specific Notices for PTC 209
For research use only
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