PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Product Specifications

Molecular Weight

1214.62

Formula

C₆₃H₁₁₁N₁₁O₁₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

CAS Number

121584-18-7

PubChem ID

5281884

InChI Key

YJDYDFNKCBANTM-QCWCSKBGSA-N

SMILES

C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2

Preparing Stock Solutions for PSC 833

The following data is based on the product molecular weight 1214.62

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	41.17 mL	205.83 mL	411.65 mL
0.1 mM	8.23 mL	41.17 mL	82.33 mL
0.2 mM	4.12 mL	20.58 mL	41.17 mL
1 mM	0.82 mL	4.12 mL	8.23 mL

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Background References

References are publications that support the biological activity of the product.

Shen Dynamic assessment of mitoxan. resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 2009 PMID: 19423841
Goda Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 2007 PMID: 17050779
Shen Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 2008 PMID: 17947497
Song Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J.Pharmacol.Exp.Ther. 1998 PMID: 9864280

PSC 833

Tocris Bioscience, part of Bio-Techne | Catalog # 4042

Key Product Details

Description

Alternative Names

View all Multidrug Transporter Inhibitors »

Product Description