Cyclosporin A

Name: Cyclosporin A
Brand: Tocris Bioscience
SKU: 1101
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1101

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Citations (139)

COA / SDS

Calcineurin inhibitor

Key Product Details

Description:	Calcineurin inhibitor
Alternative Names:	Ciclosporin A
Purity:	≥98% (HPLC)
Molecular Weight:	1202.63

View Full Technical Details for Cyclosporin A

Technical Data
Citations / Reviews (1)

Biological Activity for Cyclosporin A

Cyclosporin A is an immunosuppressant; simultaneously binds calcineurin and cyclophilin and inhibits phosphatase activity of calcineurin (IC₅₀ = 5 nM). Additionally inhibits formation and opening of the mitochondrial permeability transition pore (MPTP). Also inhibits coronavirus replication in vitro. Enhances lentirival transduction of bone marrow-derived CD34⁺ cells and is additive with Prostaglandin E₂ (Cat. No. 2296).

Compound Libraries for Cyclosporin A

Cyclosporin A is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Cyclosporin A

M. Wt	1202.63
Formula	C₆₂H₁₁₁N₁₁O₁₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	59865-13-3
PubChem ID	2909
InChi Key	PMATZTZNYRCHOR-CGLBZJNRSA-N
Smiles	[H][C@@]1(C(C)C)NC([C@@H](N(C(CN(C([C@@H](NC([C@]([C@@H]([C@@H](C/C=C/C)C)O)(N(C([C@](C(C)C)(N(C([C@@H](N(C([C@](CC(C)C)(N(C([C@H](NC([C@@H](NC([C@@H](N(C1=O)C)CC(C)C)=O)C)=O)C)=O)C)[H])=O)C)CC(C)C)=O)C)[H])=O)C)[H])=O)CC)=O)C)=O)C)CC(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclosporin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	120.26	100
	ethanol	60.13	50

Preparing Stock Solutions for Cyclosporin A

The following data is based on the product molecular weight 1202.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.83 mL	4.16 mL	8.32 mL
5 mM	0.17 mL	0.83 mL	1.66 mL
10 mM	0.08 mL	0.42 mL	0.83 mL
50 mM	0.02 mL	0.08 mL	0.17 mL

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Reconstitution Calculator

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References for Cyclosporin A

References are publications that support the biological activity of the product.

Carbajo-Lozoya Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir. Virus Res. 2014 PMID: 24566223
de Wilde Cyclosporin A inhibits the replication of diverse coronaviruses. J.Gen.Virol. 2011 PMID: 21752960
de Wilde MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment. J.Gen.Virol. 2013 PMID: 23620378
Petrillo Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex vivo gene therapy settings. Hum.Gene.Ther. 2019 PMID: 31037976
Yan Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. Biochem.Biophys.Res.Commun. 2009 PMID: 19094963
Nakata Evidence that cyclosporin A and dexameth. inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells. Br.J.Pharmacol. 1998 PMID: 9723954
Fruman Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1373887
Brookemeier and Pfeiffer Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry 1995 PMID: 8845372