pCPA methyl ester hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5871
Tryptophan hydroxylase inhibitor
Product Description
pCPA methyl ester hydrochloride is a tryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine (Cat. No. 0938).Product Specifications
Molecular Weight
250.12
Formula
C10H12ClNO2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-DL-Phenylalanine methyl ester hydrochloride
CAS Number
14173-40-1
PubChem ID
26531
InChI Key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
SMILES
O=C(C(CC1=CC=C(C=C1)Cl)N)OC.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.01 | 100 | |
| DMSO | 25.01 | 100 |
Preparing Stock Solutions
for pCPA methyl ester hydrochloride
The following data is based on the product molecular weight 250.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.00 mL | 19.99 mL | 39.98 mL |
| 5 mM | 0.80 mL | 4.00 mL | 8.00 mL |
| 10 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wallace Vort. restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 2014 PMID: 24852131
- Pinto Brod Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 2016 PMID: 26596986
Product Specific Notices for pCPA methyl ester hydrochloride
For research use only
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