p-Chlorophenylalanine
Tocris Bioscience, part of Bio-Techne | Catalog # 0938
Tryptophan hydroxylase inhibitor
Key Product Details
Description
Tryptophan hydroxylase inhibitor
Product Description
p-Chlorophenylalanine is a binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.Product Specifications
Molecular Weight
199.64
Formula
C9H10ClNO2
Storage
Store at RT
Purity
≥99% (HPLC)
CAS Number
7424-00-2
PubChem ID
4652
InChI Key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
SMILES
NC(C(O)=O)CC1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 10 |
Preparing Stock Solutions
for p-Chlorophenylalanine
The following data is based on the product molecular weight 199.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 50.09 mL | 250.45 mL | 500.90 mL |
| 0.5 mM | 10.02 mL | 50.09 mL | 100.18 mL |
| 1 mM | 5.01 mL | 25.05 mL | 50.09 mL |
| 5 mM | 1.00 mL | 5.01 mL | 10.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Koyuncuoglu The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 1975 PMID: 129787
- Datla and Curzon Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 1996 PMID: 8783206
Product Specific Notices for p-Chlorophenylalanine
For research use only
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