Olomoucine

Name: Olomoucine
Brand: Tocris Bioscience
SKU: 1284

Tocris Bioscience, part of Bio-Techne | Catalog # 1284

Citations (8)

COA / SDS

Cdk inhibitor

Discontinued Product

1284 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description:	Cdk inhibitor
Chemical Name:	6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
Molecular Weight:	298.35

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Technical Data
Citations

Biological Activity for Olomoucine

ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.6 and 0.94 - 8 μM for cdk7 and cdk2 respectively, and >1 μM for cdk1 and cdk9. Induces cell cycle arrest at G1 in human fibroblasts.

Technical Data for Olomoucine

M. Wt	298.35
Formula	C₁₅H₁₈N₆O
Storage	Desiccate at -20°C
CAS Number	101622-51-9
PubChem ID	4592
InChi Key	GTVPOLSIJWJJNY-UHFFFAOYSA-N
Smiles	CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Olomoucine

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Alessi The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 1998 PMID: 9828096
Vesely Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 1994 PMID: 7925396
Abraham Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 1995 PMID: 7549905

Olomoucine

Tocris Bioscience, part of Bio-Techne | Catalog # 1284

Key Product Details

Biological Activity for Olomoucine

Technical Data for Olomoucine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Olomoucine

Product Documents for Olomoucine

COA

Certificate of Analysis

SDS

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