NVP ADW 742

Name: NVP ADW 742
Brand: Tocris Bioscience
SKU: 5247

Tocris Bioscience, part of Bio-Techne | Catalog # 5247

Citations (1)

COA / SDS

ATP-competitive inhibitor of IGF1R

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Technical Data
Citations

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

ATP-competitive inhibitor of IGF1R

View all Insulin and Insulin-like Receptor Inhibitors »

Product Description

NVP ADW 742 is an ATP-competitive inhibitor of IGF1R (IC₅₀ in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC₅₀ in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib (Cat. No. 5906), enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics Etoposide (Cat. No. 1226) and Carboplatin (Cat. No. 2626).

Product Specifications

Molecular Weight

453.58

Formula

C₂₈H₃₁N₅O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

CAS Number

475488-23-4

PubChem ID

9825149

InChI Key

LSFLAQVDISHMNB-UHFFFAOYSA-N

SMILES

NC1=NC=NC2=C1C(C4=CC(OCC5=CC=CC=C5)=CC=C4)=CN2[C@@H]3C[C@@H](CN6CCCC6)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.68	50
	Ethanol	4.54	10

Preparing Stock Solutions for NVP ADW 742

The following data is based on the product molecular weight 453.58

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.41 mL	22.05 mL	44.09 mL
2.5 mM	0.88 mL	4.41 mL	8.82 mL
5 mM	0.44 mL	2.20 mL	4.41 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Warshamana-Greene The Ins-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol.Cancer Ther. 2004 PMID: 15141010
Zhou The Ins-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 2011 PMID: 21455580
Warshamana-Greene The Ins-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin.Cancer Res. 2005 PMID: 15746061