Carboplatin

Name: Carboplatin
Brand: Tocris Bioscience
SKU: 2626
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2626

(1)

Citations (42)

COA / SDS

DNA cross-linking antitumor agent

Key Product Details

Description:	DNA cross-linking antitumor agent
Alternative Names:	NSC 241240,Paraplatin,JM 8
Chemical Name:	cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Purity:	≥98% (HPLC)
Molecular Weight:	371.25

View Full Technical Details for Carboplatin

Technical Data
Citations / Reviews (1)

Biological Activity for Carboplatin

Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).

Technical Data for Carboplatin

M. Wt	371.25
Formula	C₆H₁₂N₂O₄Pt
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	41575-94-4
PubChem ID	10339178
InChi Key	OLESAACUTLOWQZ-UHFFFAOYSA-L
Smiles	O=C(C21CCC2)O[Pt-2]([NH3+])([NH3+])OC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Carboplatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	9.28	25

Preparing Stock Solutions for Carboplatin

The following data is based on the product molecular weight 371.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.77 mL	53.87 mL	107.74 mL
1.25 mM	2.15 mL	10.77 mL	21.55 mL
2.5 mM	1.08 mL	5.39 mL	10.77 mL
12.5 mM	0.22 mL	1.08 mL	2.15 mL

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Reconstitution Calculator

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References for Carboplatin

References are publications that support the biological activity of the product.

Thomas High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity. Mol.Pharmacol. 2006 PMID: 16569706
Yang Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res.
Natarajan Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 1999 PMID: 10535754

Product Documents for Carboplatin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Carboplatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov