NAB 2

Tocris Bioscience, part of Bio-Techne | Catalog # 5131

Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
Discontinued Product
5131 has been discontinued. View all Ubiquitin Ligase (E3) Inhibitors products.

Key Product Details

Description

Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

NAB 2 protects against α-synuclein toxicity. NAB 2 reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. NAB 2 promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Product Specifications

Molecular Weight

389.88

Formula

C23H20ClN3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide

CAS Number

1504588-00-4

PubChem ID

82017756

InChI Key

CZSLEMCYYGEGKP-UHFFFAOYSA-N

SMILES

O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.99 100
Ethanol 38.99 100

Preparing Stock Solutions for NAB 2

The following data is based on the product molecular weight 389.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for NAB 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NAB 2

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.