MM 54
Tocris Bioscience, part of Bio-Techne | Catalog # 5992
Potent apelin antagonist
Product Description
MM 54 is a potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.Product Specifications
Molecular Weight
1737.15
Formula
C70H121N29O15S4
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
1313027-43-8
PubChem ID
122705991
InChI Key
BMJYNYGARUVBJU-CSRTWURCSA-N
SMILES
[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Harford-Wright Pharmacological targeting of apelin impairs glioblastoma growth. Brain 2017 PMID: 29053791
- Macaluso Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 2011 PMID: 21560248
Product Specific Notices for MM 54
For research use only
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