[Pyr1]-Apelin-13
Tocris Bioscience, part of Bio-Techne | Catalog # 2420
Potent peptide apelin agonist
Key Product Details
Description
Potent peptide apelin agonist
Alternative Names
[pGlu1]-Apelin-13
Product Description
[Pyr1]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.Product Specifications
Molecular Weight
1533.81
Formula
C69H108N22O16S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
217082-60-5
PubChem ID
25085173
InChI Key
GGMAXEWLXWJGSF-PEWBXTNBSA-N
SMILES
[H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Kleinz Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 2005 PMID: 15907343
- Kagiyama Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 2005 PMID: 15582714
- Tatemoto Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm.
- Katugampola [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 2001 PMID: 11250876
Product Specific Notices for [Pyr1]-Apelin-13
For research use only
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