M8 B hydrochloride

Name: M8 B hydrochloride
Brand: Tocris Bioscience
SKU: 5324

Tocris Bioscience, part of Bio-Techne | Catalog # 5324

Citations (2)

COA / SDS

Potent and selective TRPM8 channel blocker

Key Product Details

Description:	Potent and selective TRPM8 channel blocker
Chemical Name:	N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	432.96

View Full Technical Details for M8 B hydrochloride

Technical Data
Citations

Biological Activity for M8 B hydrochloride

M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC₅₀ values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC₅₀ > 20 μM). Reduces body temperature in vivo.

Compound Libraries for M8 B hydrochloride

M8 B hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for M8 B hydrochloride

M. Wt	432.96
Formula	C₂₂H₂₄N₂O₃S.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	883976-12-3
PubChem ID	69316632
InChi Key	FMQJBHACRTZLME-UHFFFAOYSA-N
Smiles	COC1=C(OCC2=CC=CC=C2)C=CC(CN(CCN)C(C3=CC=CS3)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M8 B hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.33	10 with sonication
	DMSO	43.3	100

Preparing Stock Solutions for M8 B hydrochloride

The following data is based on the product molecular weight 432.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.55 mL	23.10 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for M8 B hydrochloride

References are publications that support the biological activity of the product.

Almeida Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 2012 PMID: 22323721