L-748,337

Name: L-748,337
Brand: Tocris Bioscience
SKU: 2760

Tocris Bioscience, part of Bio-Techne | Catalog # 2760

Citations (22)

COA / SDS

Selective β3 antagonist

Key Product Details

Description:	Selective β₃ antagonist
Chemical Name:	N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	497.61

View Full Technical Details for L-748,337

Technical Data
Citations

Biological Activity for L-748,337

L-748,337 is a competitive β₃-adrenoceptor antagonist that displays selectivity over β₁ and β₂ receptors (K_i values are 4.0, 204 and 390 nM for β₃-, β₂- and β₁-adrenoceptors respectively). Inhibits cAMP accumulation in response to Isoproterenol (IC₅₀ = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.

Compound Libraries for L-748,337

L-748,337 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-748,337

M. Wt	497.61
Formula	C₂₆H₃₁N₃O₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	244192-94-7
PubChem ID	10028830
InChi Key	AWIONHVPTYTSHZ-DEOSSOPVSA-N
Smiles	O[C@H](COC2=CC=CC(CNC(C)=O)=C2)CNCCC1=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-748,337

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.76	100
	ethanol	4.98	10

Preparing Stock Solutions for L-748,337

The following data is based on the product molecular weight 497.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.05 mL	20.10 mL
5 mM	0.40 mL	2.01 mL	4.02 mL
10 mM	0.20 mL	1.00 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for L-748,337

References are publications that support the biological activity of the product.

Neidhold The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br.J.Pharmacol. 2007 PMID: 17179950
Dal Monte β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch.Pharmacol. 2014 PMID: 24599317
Candelore Potent and selective human β₃-adrenergic receptor antagonist. J.Pharmacol.Exp.Ther. 1999 PMID: 10411574