Isoproterenol hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1747
Key Product Details
| Description: | Standard selective β agonist |
| Alternative Names: | Isoprenaline |
| Chemical Name: | 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride |
| Purity: | ≥98% (HPLC) |
| Molecular Weight: | 247.72 |
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Small molecules affect the rate of cardiomyocyte contraction. Cardiomyocytes were differentiated from the BG01V human embryonic stem cells and assessed for their ability to contract using the Fluo-4 calcium binding assay. Rate interval graph show fluctuations in Fluo-4 fluorescence intensity, indicative of cardiomyocyte contraction, under basal conditions (brown; untreated) and following sequential treatment with Isoproterenol (blue; Catalog # 1747), a beta -adrenergic agonist, and Propranolol (tan; Catalog # 0624), a beta -adrenergic antagonist. Table shows drug concentrations and contraction rate of cardiomyocytes during each treatment. The contraction rate of differentiated cardiomyocytes was determined as the number of contractions (contraction-interval plus relaxation interval) per minute. |