KN 93 phosphate
Tocris Bioscience, part of Bio-Techne | Catalog # 5215
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
Key Product Details
Description
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
Product Description
KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).Product Specifications
Molecular Weight
599.03
Formula
C26H29ClN2O4S.H3PO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
CAS Number
1188890-41-6
PubChem ID
16760530
InChI Key
NNKJTPOXLIILMB-IPZCTEOASA-N
SMILES
O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O.O=P(O)(O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.99 | 10 |
Preparing Stock Solutions
for KN 93 phosphate
The following data is based on the product molecular weight 599.03
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.69 mL | 83.47 mL | 166.94 mL |
| 0.5 mM | 3.34 mL | 16.69 mL | 33.39 mL |
| 1 mM | 1.67 mL | 8.35 mL | 16.69 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bruno Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II. Synthesis
- Sumi The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 1991 PMID: 1662507
- Rezazadeh KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 2006 PMID: 16368898
- Anderson KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 1998 PMID: 9864285
Product Specific Notices for KN 93 phosphate
For research use only
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