GSK 2033

Name: GSK 2033
Brand: Tocris Bioscience
SKU: 5694

Tocris Bioscience, part of Bio-Techne | Catalog # 5694

Citations (33)

COA / SDS

Potent LXR antagonist

Key Product Details

Description:	Potent LXR antagonist
Chemical Name:	2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	591.66

View Full Technical Details for GSK 2033

Technical Data
Citations

Biological Activity for GSK 2033

GSK 2033 is a potent LXR antagonist (pIC₅₀ = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.

Compound Libraries for GSK 2033

GSK 2033 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2033

M. Wt	591.66
Formula	C₂₉H₂₈F₃NO₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1221277-90-2
PubChem ID	46203250
InChi Key	PSOXOVKYGWBTPB-UHFFFAOYSA-N
Smiles	CC1=CC(C)=CC(C)=C1S(N(CC2=CC=C(C(F)(F)F)O2)CC(C=C3)=CC=C3C4=CC(S(C)(=O)=O)=CC=C4)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2033

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.83	20

Preparing Stock Solutions for GSK 2033

The following data is based on the product molecular weight 591.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.45 mL	42.25 mL	84.51 mL
1 mM	1.69 mL	8.45 mL	16.90 mL
2 mM	0.85 mL	4.23 mL	8.45 mL
10 mM	0.17 mL	0.85 mL	1.69 mL

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References for GSK 2033

References are publications that support the biological activity of the product.

Solt LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE 2012 PMID: 23029557
Zuercher Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem. 2010 PMID: 20345102