T 0901317

Product Description

T 0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC₅₀ ~ 50 nM, K_d values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC₅₀ of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

Solubility

Preparing Stock Solutions for T 0901317

The following data is based on the product molecular weight 481.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.39 mL	20.78 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kanno T0901317, a potent LXR agonist, is an inverse agonist of CAR. J.Toxicol.Sci. 2013 PMID: 23665929
• Mitro The nuclear receptor LXR is a glucose sensor. Nature Lett.
• Koldamova The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. J.Biol.Chem. 2005 PMID: 15557325
• Houck T0901317 is a dual LXR/FXR agonist. Mol.Gen.Metab.
• Repa Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000 PMID: 10968783