Gossypol
Tocris Bioscience, part of Bio-Techne | Catalog # 1964
Proapoptotic; downregulates Bcl-2 and Bcl-XL
Discontinued Product
1964 has been discontinued.
View all Additional Bcl-2 Family Compounds products.
Key Product Details
Description
Proapoptotic; downregulates Bcl-2 and Bcl-XL
Product Description
Gossypol is a lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.R-enantiomer also available.
Product Specifications
Molecular Weight
518.56
Formula
C30H30O8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
CAS Number
303-45-7
PubChem ID
3503
InChI Key
QBKSWRVVCFFDOT-UHFFFAOYSA-N
SMILES
CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(=C(C)C=C12)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.96 | 25 | |
| Ethanol | 12.96 | 25 with gentle warming |
Preparing Stock Solutions
for Gossypol
The following data is based on the product molecular weight 518.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.71 mL | 38.57 mL | 77.14 mL |
| 1.25 mM | 1.54 mL | 7.71 mL | 15.43 mL |
| 2.5 mM | 0.77 mL | 3.86 mL | 7.71 mL |
| 12.5 mM | 0.15 mL | 0.77 mL | 1.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vander Jagt Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem. 2000 PMID: 10702620
- Zhang Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol. 2003 PMID: 12818369
- Coutinh Gossypol: a contraceptive for men. Contraception 2002 PMID: 12020773
Product Specific Notices for Gossypol
For research use only
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