AT 101

Tocris Bioscience, part of Bio-Techne | Catalog # 3367

Downregulates Bcl-2 and Mcl-1; pro-apoptotic
Discontinued Product
3367 has been discontinued. View all Additional Bcl-2 Family Compounds products.

Key Product Details

Description

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

View all Additional Bcl-2 Family Compounds »

Product Description

AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Product Specifications

Molecular Weight

518.56

Formula

C30H30O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

CAS Number

90141-22-3

PubChem ID

3503

InChI Key

QBKSWRVVCFFDOT-UHFFFAOYSA-N

SMILES

OC1=[C@]([C@]2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C1C(C=O)=C(O)C(O)=C4C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.37 20

Preparing Stock Solutions for AT 101

The following data is based on the product molecular weight 518.56

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.64 mL 48.21 mL 96.42 mL
1 mM 1.93 mL 9.64 mL 19.28 mL
2 mM 0.96 mL 4.82 mL 9.64 mL
10 mM 0.19 mL 0.96 mL 1.93 mL

Calculators

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Reconstitution Calculator

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Product Documents for AT 101

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AT 101

For research use only

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