Galidesivir dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 7229
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral
Key Product Details
Description
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral
Alternative Names
BCX 4430
Product Description
Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50 values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.Product Specifications
Molecular Weight
338.19
Formula
C11H15N5O3.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol dihydrochloride
CAS Number
1373208-51-5
PubChem ID
90008271
InChI Key
LOHGEHBUEDUIRK-PUSSMWDMSA-N
SMILES
NC1=NC=NC2=C1NC=C2[C@@H]3N[C@@H]([C@H]([C@H]3O)O)CO.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.82 | 100 | |
| DMSO | 16.91 | 50 |
Preparing Stock Solutions
for Galidesivir dihydrochloride
The following data is based on the product molecular weight 338.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.57 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.30 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Warren Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014 PMID: 24590073
- Li & De Clercq Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 2020 PMID: 32127666
Product Specific Notices for Galidesivir dihydrochloride
For research use only
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