CU CPT 9a
Tocris Bioscience, part of Bio-Techne | Catalog # 6479
Highly potent TLR8 inhibitor
Key Product Details
Description
Highly potent TLR8 inhibitor
Product Description
CU CPT 9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.Licensing Information
Sold under license from the University of ColoradoProduct Specifications
Molecular Weight
265.31
Formula
C17H15NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
CAS Number
2165340-32-7
PubChem ID
135567383
InChI Key
HNYBTVKYLVLWCB-UHFFFAOYSA-N
SMILES
COC1=CC2=C(C(C3=CC(C)=C(C=C3)O)=CC=N2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.53 | 100 | |
| Ethanol | 5.31 | 20 |
Preparing Stock Solutions
for CU CPT 9a
The following data is based on the product molecular weight 265.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.77 mL | 18.85 mL | 37.69 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.77 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 2018 PMID: 29155428
Product Specific Notices for CU CPT 9a
For research use only
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