CE3F4
Tocris Bioscience, part of Bio-Techne | Catalog # 4793
Noncompetitive Epac1 inhibitor
Discontinued Product
4793 has been discontinued.
View all EPAC Inhibitors products.
Product Description
CE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.Product Specifications
Molecular Weight
351.01
Formula
C11H10Br2FNO
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
CAS Number
143703-25-7
PubChem ID
21781066
InChI Key
ZZLQPWXVZCPUGC-UHFFFAOYSA-N
SMILES
BrC1=C(F)C(Br)=C(CCC(C)N2C=O)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.1 | 100 | |
| Ethanol | 17.55 | 50 |
Preparing Stock Solutions
for CE3F4
The following data is based on the product molecular weight 351.01
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.24 mL | 28.49 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.70 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Courilleau Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 2012 PMID: 23139415
- Chen The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Transl.Med.
- Laurent Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 2015 PMID: 25411381
Product Specific Notices for CE3F4
For research use only
Loading...
Loading...