cAMPS-Sp, triethylammonium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 1333
Cell-permeable cAMP analog
Product Description
cAMPS-Sp, triethylammonium salt is a cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.R-enantiomer also available.
Product Specifications
Molecular Weight
446.46
Formula
C10H12N5O5PS.C6H15N
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
CAS Number
93602-66-5
PubChem ID
57369926
InChI Key
OXIPZMKSNMRTIV-UHFFFAOYSA-N
SMILES
[H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@]1([S-])=O.CC[NH+](CC)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.65 | 100 |
Preparing Stock Solutions
for cAMPS-Sp, triethylammonium salt
The following data is based on the product molecular weight 446.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.20 mL | 22.40 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- O'Brian A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry 1982 PMID: 6289880
- Kawasaki A family of cAMP-binding proteins that directly activate Rap1. Science 1998 PMID: 9856955
- Lin Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 2006 PMID: 16806304
- Dostmann Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 1990 PMID: 2162349
Product Specific Notices for cAMPS-Sp, triethylammonium salt
For research use only
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