cAMPS-Rp, triethylammonium salt

Name: cAMPS-Rp, triethylammonium salt
Brand: Tocris Bioscience
SKU: 1337
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1337

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Citations (44)

COA / SDS

cAMP antagonist

Key Product Details

Description:	cAMP antagonist
Chemical Name:	(R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Purity:	≥98% (HPLC)
Molecular Weight:	446.46

View Full Technical Details for cAMPS-Rp, triethylammonium salt

Technical Data
Citations / Reviews (1)

Biological Activity for cAMPS-Rp, triethylammonium salt

cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC₅₀ = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.

Technical Data for cAMPS-Rp, triethylammonium salt

M. Wt	446.46
Formula	C₁₀H₁₂N₅O₅PS.C₆H₁₅N
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	151837-09-1
PubChem ID	5311365
InChi Key	FKAWLXNLHHIHLA-YCBIHMBMSA-N
Smiles	[H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@@]1([S-])=O.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cAMPS-Rp, triethylammonium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.65	100

Preparing Stock Solutions for cAMPS-Rp, triethylammonium salt

The following data is based on the product molecular weight 446.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.40 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for cAMPS-Rp, triethylammonium salt

References are publications that support the biological activity of the product.

Duca MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 2015 PMID: 25849133
Van Haastert Competitive cAMP antagonists for cAMP-receptor proteins. J.Biol.Chem. 1984 PMID: 6088478
Rothermel and Botelho A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem.J. 1988 PMID: 2843164
Kuriyama Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest.Ophthalmol.Vis.Sci. 1995 PMID: 7890503
Fu PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol.Pain 2008 PMID: 18631385
Dostmann Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 1990 PMID: 2162349