Bumetanide

Tocris Bioscience, part of Bio-Techne | Catalog # 3108

Na+/2Cl-/K+ (NKCC) symporter inhibitor
Catalog #
Availability
Size / Price
Qty
3108/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Na+/2Cl-/K+ (NKCC) symporter inhibitor

View all NKCC Cotransporter Inhibitors »

Product Description

Bumetanide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer's disease transcriptomic signatures.

Product Specifications

Molecular Weight

364.42

Formula

C17H20N2O5S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid

CAS Number

28395-03-1

PubChem ID

2471

InChI Key

MAEIEVLCKWDQJH-UHFFFAOYSA-N

SMILES

CCCCNC1=CC(C(O)=O)=CC(S(=O)(N)=O)=C1OC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100

Preparing Stock Solutions for Bumetanide

The following data is based on the product molecular weight 364.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Bumetanide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bumetanide

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.