Furosemide

Name: Furosemide
Brand: Tocris Bioscience
SKU: 3109

Tocris Bioscience, part of Bio-Techne | Catalog # 3109

Citations (27)

COA / SDS

Na+/2Cl-/K+ (NKCC) symporter inhibitor; also GABAA antagonist

Key Product Details

Description:	Na⁺/2Cl^-/K⁺ (NKCC) symporter inhibitor; also GABA_A antagonist
Chemical Name:	5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	330.74

View Full Technical Details for Furosemide

Technical Data
Citations

Biological Activity for Furosemide

Furosemide is a loop diuretic that inhibits the Na⁺/2Cl^-/K⁺ (NKCC) symporter. Also acts as a non-competitive antagonist at GABA_A receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.

Compound Libraries for Furosemide

Furosemide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Furosemide

M. Wt	330.74
Formula	C₁₂H₁₁ClN₂O₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	54-31-9
PubChem ID	3440
InChi Key	ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Smiles	ClC1=CC(NCC2=CC=CO2)=C(C(O)=O)C=C1S(=O)(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Furosemide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.07	100

Preparing Stock Solutions for Furosemide

The following data is based on the product molecular weight 330.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.12 mL	30.24 mL
5 mM	0.60 mL	3.02 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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Reconstitution Calculator

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References for Furosemide

References are publications that support the biological activity of the product.

Gutschmidt Anticonvulsant actions of Furos. in vitro. Neuroscience 1999 PMID: 10391452
Thompson Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by Furos.. Mol.Pharmacol. 1999 PMID: 10347239