BMH 21

Name: BMH 21
Brand: Tocris Bioscience
SKU: 5417

Tocris Bioscience, part of Bio-Techne | Catalog # 5417

Citations (3)

COA / SDS

RNA polymerase I inhibitor; also p53 pathway activator

Key Product Details

Description:	RNA polymerase I inhibitor; also p53 pathway activator
Chemical Name:	N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	360.41

View Full Technical Details for BMH 21

Technical Data
Citations

Biological Activity for BMH 21

BMH 21 is a p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Technical Data for BMH 21

M. Wt	360.41
Formula	C₂₁H₂₀N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	896705-16-1
PubChem ID	3508054
InChi Key	BXYDVWIAGDJBEC-UHFFFAOYSA-N
Smiles	O=C2N4C(C(C(NCCN(C)C)=O)=CC=C4)=NC(C2=C3)=CC1=C3C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMH 21

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.8	5 with gentle warming

Preparing Stock Solutions for BMH 21

The following data is based on the product molecular weight 360.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	55.49 mL	277.46 mL	554.92 mL
0.25 mM	11.10 mL	55.49 mL	110.98 mL
0.5 mM	5.55 mL	27.75 mL	55.49 mL
2.5 mM	1.11 mL	5.55 mL	11.10 mL

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References for BMH 21

References are publications that support the biological activity of the product.

Colis Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 2014 PMID: 24847734
Peltonen Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 2010 PMID: 20885994
Peltonen A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 2014 PMID: 24434211