AMTB hydrochloride

Name: AMTB hydrochloride
Brand: Tocris Bioscience
SKU: 3989

Tocris Bioscience, part of Bio-Techne | Catalog # 3989

Citations (20)

COA / SDS

TRPM8 blocker

Key Product Details

Description:	TRPM8 blocker
Chemical Name:	N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	430.99

View Full Technical Details for AMTB hydrochloride

Technical Data
Citations

Biological Activity for AMTB hydrochloride

AMTB hydrochloride is a TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC₅₀ = 6.23).

Technical Data for AMTB hydrochloride

M. Wt	430.99
Formula	C₂₃H₂₆N₂O₂S.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	926023-82-7
PubChem ID	16095383
InChi Key	UDXGBANGPYONOK-UHFFFAOYSA-N
Smiles	O=C(N(CC2=CC=CS2)CCCN)C1=C(OCC3=CC(C)=CC=C3)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMTB hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.1	100
	DMSO	43.1	100

Preparing Stock Solutions for AMTB hydrochloride

The following data is based on the product molecular weight 430.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.60 mL	23.20 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for AMTB hydrochloride

References are publications that support the biological activity of the product.

Lashinger AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am.J.Physiol.Renal Physiol. 2008 PMID: 18562636