Ac-RYYRIK-NH₂

Name: Ac-RYYRIK-NH 2
Brand: Tocris Bioscience
SKU: 1239

Tocris Bioscience, part of Bio-Techne | Catalog # 1239

COA / SDS

High affinity NOP ligand

Discontinued Product

1239 has been discontinued. View all NOP Receptor Ligands products.

Key Product Details

Description:	High affinity NOP ligand
Molecular Weight:	939.12

View Full Technical Details for Ac-RYYRIK-NH₂

Technical Data
Citations

Biological Activity for Ac-RYYRIK-NH₂

Ac-RYYRIK-NH₂ is a high affinity ligand for the NOP site (K_i = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.

Technical Data for Ac-RYYRIK-NH₂

M. Wt	939.12
Formula	C₄₄H₇₀N₁₄O₉
Single Letter Sequence	RYYRIK (Modifications: Arg-1 = N-terminal Ac, Lys-6 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	200959-48-4
PubChem ID	9963005
InChi Key	WBBBVZGQADABSU-RERZDIOCSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ac-RYYRIK-NH₂

References are publications that support the biological activity of the product.

Berger Acetyl-RYYRIK-NH₂, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well. Regul.Pept. 1999 PMID: 10998548
Dooley Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL₁. J.Pharmacol.Exp.Ther. 1997 PMID: 9353393
Berger Antagonism by acetyl-RYYRIK-NH₂ of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 1999 PMID: 10188961

Product Documents for Ac-RYYRIK-NH₂

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.

Ac-RYYRIK-NH₂

Tocris Bioscience, part of Bio-Techne | Catalog # 1239

Key Product Details

Biological Activity for Ac-RYYRIK-NH₂

Technical Data for Ac-RYYRIK-NH₂

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ac-RYYRIK-NH₂

Product Documents for Ac-RYYRIK-NH₂

COA

SDS

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Ac-RYYRIK-NH2

Tocris Bioscience, part of Bio-Techne | Catalog # 1239

Key Product Details

Biological Activity for Ac-RYYRIK-NH2

Technical Data for Ac-RYYRIK-NH2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ac-RYYRIK-NH2

Product Documents for Ac-RYYRIK-NH2

COA

SDS

Ac-RYYRIK-NH₂

Biological Activity for Ac-RYYRIK-NH₂

Technical Data for Ac-RYYRIK-NH₂

References for Ac-RYYRIK-NH₂

Product Documents for Ac-RYYRIK-NH₂