A 943931 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3753

Potent and selective H4 antagonist
Discontinued Product
3753 has been discontinued. View all Histamine H4 Receptor Antagonists products.

Key Product Details

Description

Potent and selective H4 antagonist

View all Histamine H4 Receptor Antagonists »

Product Description

A 943931 dihydrochloride is a potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.

Product Specifications

Molecular Weight

368.31

Formula

C17H21N5.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine

CAS Number

1227675-50-4

PubChem ID

56972240

InChI Key

ISYUFRNZHUOGLA-CURYUGHLSA-N

SMILES

NC1=NC(N4C[C@H](N)CC4)=C2C(C(C=CC=C3)=C3CCC2)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.83 100
DMSO 36.83 100

Preparing Stock Solutions for A 943931 dihydrochloride

The following data is based on the product molecular weight 368.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.58 mL 27.15 mL
5 mM 0.54 mL 2.72 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Product Documents for A 943931 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 943931 dihydrochloride

For research use only

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