8-Hydroxy-DPAT hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 0529
Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
Discontinued Product
0529 has been discontinued.
View all 5-HT1 Receptor Agonists products.
Key Product Details
Description
Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
Alternative Names
8-OH-DPAT hydrobromide
Product Description
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.R-enantiomer and 7-Hydroxy Isomer also available..
Product Specifications
Molecular Weight
328.29
Formula
C16H25NO.HBr
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide
CAS Number
76135-31-4
PubChem ID
6917794
InChI Key
BATPBOZTBNNDLN-UHFFFAOYSA-N
SMILES
Br.CCCN(CCC)C1CCC2=CC=CC(O)=C2C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.28 | 10 with gentle warming | |
| DMSO | 16.41 | 50 |
Preparing Stock Solutions
for 8-Hydroxy-DPAT hydrobromide
The following data is based on the product molecular weight 328.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.09 mL | 30.46 mL | 60.92 mL |
| 2.5 mM | 1.22 mL | 6.09 mL | 12.18 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.09 mL |
| 25 mM | 0.12 mL | 0.61 mL | 1.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yoshitake and Kehr Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004 PMID: 15050424
- Middlemiss 8-OH-DPAT discriminates between subtypes of the 5HT1 recognition site. Eur.J.Pharmacol. 1983 PMID: 6223827
- Wood Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 2000 PMID: 10822046
- Helton and Colbert Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 1994 PMID: 7897596
Product Specific Notices for 8-Hydroxy-DPAT hydrobromide
For research use only
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