Recombinant Bacteria Zinc metalloprotease-1 His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18169

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Key Product Details

Source

E. coli

Accession #

O53649

Tag

His

Conjugate

Unconjugated

Applications

Enzyme Activity

View all Zinc metalloprotease-1 Proteins and Enzymes »

Product Specifications

Description

Full-length Zmp1 (Mycobacterium tuberculosis) fused at the N-terminus to a His-tag.

Source: E. coli

Uniprot ID: O53649

Purity

>98%, by SDS-PAGE

Predicted Molecular Mass

73.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

~0.5U/mg protein Active towards the generic fluorogenic substrate for matrix metalloproteinases MMP2/MMP7

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP3-18169
Formulation 10mM TRIS-HCl, pH 8.0
Preservative No Preservative
Concentration Please see the vial label for concentration. If unlisted please contact technical services.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

Background: Zinc metalloprotease-1

M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1 beta into IL-1 beta and the consequent phagosome maturation.

Alternate Names

Endopeptidase, peptidase family M13, Zmp1

UniProt

O53649 (Bacteria)

Additional Zinc metalloprotease-1 Products

Product Documents for Recombinant Bacteria Zinc metalloprotease-1 His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Bacteria Zinc metalloprotease-1 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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