Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

mFluor Violet 610 SE (Excitation = 421 nm, Emission = 613 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 519106

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SOCS-7/Nck/NAP4 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human SOCS-7
His351-Thr581
Accession # O14512

Specificity

Detects endogenous human SOCS-7 in Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for SOCS-7/Nck/NAP4 Antibody (519106) [mFluor Violet 610 SE]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SOCS-7/Nck/NAP4

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Long Name

Suppressor Of Cytokine Signaling 7

Alternate Names

NAP4, Nck, SOCS7

Gene Symbol

SOCS7

Additional SOCS-7/Nck/NAP4 Products

Product Documents for SOCS-7/Nck/NAP4 Antibody (519106) [mFluor Violet 610 SE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SOCS-7/Nck/NAP4 Antibody (519106) [mFluor Violet 610 SE]

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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