MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-60988

Novus Biologicals, part of Bio-Techne
Discontinued Product
NB110-60988 has been discontinued. View all MMP-7 products.

Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin, IF/IHC

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # MM0022-4C21

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all MMP-7 Antibodies »

Product Specifications

Immunogen

Human recombinant MMP-7

Specificity

This antibody recognizes human MMP-7 in western blot without cross reactivity with other human MMPs. Recognizes both pro- (28 kDa) and active-form (18 kDa).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free

Immunohistochemistry-Paraffin: MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free [NB110-60988]

Immunohistochemistry-Paraffin: MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free [NB110-60988]

Immunohistochemistry-Paraffin: MMP-7 Antibody (MM0022-4C21) [NB110-60988] - Formalin fixed and Paraffin embedded human placenta tissue section was subjected to IHC staining using NB110-60988.
MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free

Western Blot Shows MMP-7 Specificity Using Knockout Cell Line.

Western blot shows lysates of A549 human lung carcinoma parental cell line and MMP-7 knockout A549 cell line (KO). Nitrocellulose membrane was probed with MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free (Catalog # NB110-60988) followed by HRP-conjugated secondary antibody. A specific band was detected for MMP-7 at approximately 29.7 kDa (as indicated) in the parental A549 cell line, but is not detectable in knockout A549 cell line. Primary antibody dilution used: 1/1000. The Ponceau stained transfer of the blot is shown. This experiment was conducted under reducing conditions. Image, protocol, and testing courtesy of YCharOS Inc. See ycharos.com for additional details.

Applications for MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50-200

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.2 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: MMP-7

Matrix Metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are thus important in apoptosis, tumor cell growth, invasion, and metastasis, as well as angiogenesis and wound healing. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin like (Hpx) domain. MMP7, also known as Matrilysin, is responsible for hydrolyzing proteoglycans and ECM glycoproteins. It is expressed in normal cells, specifically glandular epithelial cells. MMP7, is thought to play an important role in the early steps of tumor progression. Expression of MMP2, MMP7 and MMP11 is greater in pancreatic carcinoma than in normal pancreas.

Long Name

Matrix Metalloproteinase 7

Alternate Names

Matrilysin, MMP7

Entrez Gene IDs

4316 (Human)

Gene Symbol

MMP7

UniProt

P09237

Additional MMP-7 Products

Product Documents for MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MMP-7 Antibody (MM0022-4C21) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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