VIGR (Vascular Inducible G Protein-coupled Receptor), also known as ADGRG6, DREG, and GPR126, is a neuronal 7 TM pass (G protein)-coupled receptor (GPCR) involved in myelination and glial and Schwann cell development (1, 2). Human VIGR cDNA encodes a 1221 amino acid (aa) residue membrane protein with a 37 aa signal peptide, a 825 aa extracellular domain (ECD) with 27 potential N-linked glycosylation sites, seven transmembrane segments that span between aa 863 and aa 1113, and a 108 aa residue cytoplasmic domain. Within ECD human VIGR shares 83% aa sequence identity with mouse and rat VIGR. VIGR is essential for the development of diverse organs (1, 2). Type IV collagen, a major constituent of the basement membrane, binds to VIGR and activates its signaling function (3). This interaction stimulated the production of cAMP in rodent Schwann cells, which require VIGR activity to differentiate, and in human embryonic kidney (HEK293) cells expressing exogenous VIGR. Laminin-211 binds a novel laminin-binding domain in VIGR N-terminal fragment between aa 446 and 807 (4). VIGR-Laminin-211 interactions regulate terminal differentiation and myelination by ensuring appropriate levels of cAMP for a given stage of Schwann cell development (4).

References

Rughetti, A. et al. (2005) J. Immunol. 174:7764.
Engelstaedter, V. et al. (2012) BMC Cancer 12:600.
Taylor-Papadimitriou, J. et al. (1999) Biochim. Biophys. Acta 1455:301.
Geng, Y. et al. (2012) Front Oncol. 2:76.
Tanida, S. et al. (2013) J Biol Chem. 288:31842.
Beatson, R. et al. (2016) Nat Immunol. 17:1273.
Piyush, T. et al. (2017) Cell Death Differ. 24:1937.

Long Name

Vascular-inducible G Protein-coupled Receptor

Alternate Names

APG1, DREG, Gm222, GPR126, PS1TP2

Entrez Gene IDs

57211 (Human); 215798 (Mouse); 308376 (Rat)

Gene Symbol

ADGRG6

UniProt

AAH75798.1

Additional VIGR/GPR126 Products

Product Documents

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Citations
Reviews

Spectra Viewer
Flow Cytometry

Human VIGR/GPR126 Alexa Fluor™ Plus 594-conjugated MAb (Clone 1044430)

R&D Systems, part of Bio-Techne | Catalog # FAB10577AFP594

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

View all VIGR/GPR126 Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications

Flow Cytometry

Formulation, Preparation, and Storage

Formulation

Shipping

Stability & Storage

Background: VIGR/GPR126