Human Tissue alpha-L-Fucosidase/FUCA1 Alexa Fluor™ Plus 647-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF7039AFP647

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AF7039AFP647-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Polyclonal Sheep IgG

View all Tissue alpha-L-Fucosidase/FUCA1 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Tissue alpha-L-Fucosidase/FUCA1

Specificity

Detects human Tissue alpha-L-Fucosidase/FUCA1 in direct ELISAs and Western blots.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Tissue alpha-L-Fucosidase/FUCA1

Fucosylated glycoconjugates play numerous roles in biological processes, such as development, apoptosis and the immune responses, and are involved in the pathology of inflammation, cancer and cystic fibrosis (1, 2, 3, 4). Tissue alpha‑L‑Fucosidase, also known as FUCA1, is a lysosomal enzyme responsible for hydrolyzing alpha‑L‑fucose moieties from glycolipids and oligosaccharides (5). The mature enzyme in the liver has a molecular weight of 200 kDa and exists in the native state as a tetramer (6). Defects in FUCA1 are the cause of fucosidosis (7, 8, 9), an autosomal recessive lysosomal storage disease characterized by the accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Serum alpha‑L‑fucosidase has been identified as a useful marker for oral cancer (10).

References

  1. Hiraishi, K. et al. (1993) Glycobiology 3:381.
  2. Solter, D. and Knowles, B.B. (1978) Proc. Natl. Acad. Sci. USA 75:5565.
  3. Becker, D.J. and Lowe, J.B. (2003) Glycobiology 13:41R.
  4. Liu, T.W. et al. (2009) Proc. Natl. Acad. Sci. USA 106:14581.
  5. Fukushima, H. et al. (1985) Proc. Natl. Acad. Sci. USA 82:1262.
  6. Alhadeff, J.A. et al. (1975) J. Biol. Chem. 250:7106.
  7. O’Brien, J.S. et al. (1987) Enzyme 38:45.
  8. Durand, P. et al. (1969) J. Pediatr. 75:665.
  9. Johnson, K. and Dawson, G. (1985) Biochem. Biophys. Res. Commun. 133:90.
  10. Shah, M. et al. (2008) Cancer 113:336.

Alternate Names

FUCA1, Tissue alphaLFucosidase

Entrez Gene IDs

2517 (Human); 71665 (Mouse); 24375 (Rat)

Gene Symbol

FUCA1

UniProt

P04066

Additional Tissue alpha-L-Fucosidase/FUCA1 Products

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Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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