Human SOX14 Alexa Fluor™ Plus 555-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11693AFP555

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FAB11693AFP555-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 555 (Excitation = 558 nm, Emission = 572 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 1100814

View all SOX14 Antibodies »

Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide specific for human SOX14 around amino acid 190 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human SOX14 Alexa Fluor™ Plus 555-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SOX14

SOX14 is a 36 kDa protein that belongs to the SOX (SRY-related HMG-box) family of transcription factors. It plays a crucial role in the development and differentiation of the central nervous system and is critically involved in the regulation of embryogenesis, neural differentiation, and the development of specific neuronal populations. Aberrant expression or mutations of SOX14 have been associated with developmental disorders, including speech and cognitive impairments, as well as various cancers such as medulloblastoma and glioblastoma where it impacts cell proliferation, migration, and survival pathways. SOX14 is also essential for proper neural crest cell development and is implicated in neural tube defects when dysregulated. This makes it an important biomarker for neurological development and related pathologies.

References

  1. Yao L, Zhang J, Xing B, Chen F, Zhang G, Teng Q, Jin J. SOX14 promotes glioma cell proliferation and invasion by suppressing p53 signaling. Oncotarget. 2018 Jun 12;9(45):27646-27657. doi: 10.18632/oncotarget.25542. PMID: 29983854; PMCID: PMC6029639. 
  2. Smit R, Louw S, Stevens J, Kay V. SOX14 is critical for neural crest cell differentiation and neural tube closure in murine embryonic development. J Neurosci Res. 2021 May;99(5):1131-1140. doi: 10.1002/jnr.24759. PMID: 33577345; PMCID: PMC8489940.

Long Name

SRY (sex determining region Y)-box 14

Alternate Names

SOX28

Entrez Gene IDs

8403 (Human); 20669 (Mouse); 300954 (Rat)

Gene Symbol

SOX14

UniProt

O95416 (Mouse)

Additional SOX14 Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human SOX14 Alexa Fluor™ Plus 555-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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