SIRP beta1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. Members of this family are characterized by an extracellular region containing a V-set Ig domain containing a J-like sequence and two C1-set Ig domains. Unlike SIRP alpha that has cytoplasmic ITIM domains, SIRP beta1 possesses positively charged residues that allow association with ITAM motif containing adaptor molecules. SIRP beta1 is expressed on cells of monocyte, macrophage or dendritic lineages.

Long Name

Signal-regulatory Protein beta 1

Alternate Names

CD172b, SIRPB1

Entrez Gene IDs

10326 (Human); 102139733 (Cynomolgus Monkey)

Gene Symbol

SIRPB1

UniProt

O00241.4

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Product Specific Notices

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Human SIRP beta1/CD172b Alexa Fluor™ Plus 647-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB20961AFP647

Key Product Details

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Antibody Source

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Product Specifications

Immunogen

Specificity

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Isotype

Applications

CyTOF-ready

Flow Cytometry

Immunocytochemistry

Formulation, Preparation, and Storage

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Background: SIRP beta 1/CD172b