Human PTGDR Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11249AFP488

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FAB11249AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 1052528

View all PTGDR Antibodies »

Product Specifications

Immunogen

Synthetic peptide within amino acids 50-150 of the Prostaglandin D2 receptor protein sequences

Specificity

Detects Prostaglandin D2 receptor immunogen in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human PTGDR Alexa Fluor™ Plus 488-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PTGDR

PTGDR is a G protein-coupled receptor that has been shown to function as a prostanoid DP receptor. PTGDR is expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of PTGDR, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea.

Long Name

Prostaglandin D2 Receptor

Alternate Names

AS1, ASRT1, DP, DP1, PTGDR1

Entrez Gene IDs

5729 (Human); 19214 (Mouse); 498475 (Rat)

Gene Symbol

PTGDR

UniProt

Q13258 (Human)

Additional PTGDR Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human PTGDR Alexa Fluor™ Plus 488-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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