Human Phospho-RelA/NFkB p65 (S529) Alexa Fluor™ Plus 647-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB7624AFP647
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)
Antibody Source
Monoclonal Mouse IgG2A Clone # 795217
Product Specifications
Immunogen
Phosphopeptide containing the human RelA/NF kappaB p65 S529 site
Specificity
Detects human RelA/NF kappaB p65 when phosphorylated at S529
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: RelA/NFkB p65
RelA belongs to a family of transcription factors (NF kappaB (nuclear factor kappa from B cells) complex) that play a fundamental role in inflammatory and immune responses. The NF kappaB complex is composed of a heterodimer of a Rel family member (RelA, c-Rel, RelB) and either NF kappaB1 or NF kappaB2 subunits. RelA and NF kappaB1 are the most common heterodimeric pair. The NF kappaB complex is sequestered in the cytoplasm by inhibitory I kappaB proteins. Upon cellular activation, the ubiquitin-proteosome pathway degrades the I kappaB proteins allowing the NF kappaB complex to translocate to the nucleus and activate gene transcription.
Long Name
v-rel Reticuloendotheliosis Viral Oncogene Homolog A
Alternate Names
NFkB p65, NFKB3, p65RelA
Entrez Gene IDs
5970 (Human)
Gene Symbol
RELA
UniProt
Additional RelA/NFkB p65 Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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